“Attention should be given to possible masked renal damage in clinical practice for the management of CS,” they wrote. The researchers also cautioned that kidney damage may go undetected in Cushing’s patients, and advised doctors to monitor for this possibility. The adrenal glands produce steroid and other hormones that help regulate blood pressure, kidney function, responses to stress, and some sexual functions. “In conclusion,” the researchers wrote, “a persistent, but not progressive, significant decrease in eGFR was seen after adrenalectomy in patients with CS, as it was reported in patients with. Nevertheless, the study determined that Cushing’s patients experience a significant decrease in kidney function following adrenal gland removal. The outer part of the gland is called the cortex. Information Each adrenal gland is about the size of the top part of the thumb. One gland is located on top of each kidney. Additionally, higher levels of cortisol could be causing the elevated blood pressure measurement, explaining why the systolic blood pressure was higher in patients who experienced post-operative renal impairment. The adrenal glands are two small triangle-shaped glands in the upper abdomen. Therefore, the kidney damage experienced after surgery might be due to the sudden correcting of the excess filtration that comes from adrenal gland removal. Aldosterone can cause this in aldosteronism patients, and the researchers speculate that cortisol can cause this as well. From these data, the researchers suggested that a phenomenon called glomerular hyperfiltration was taking place: when the kidneys are performing, filtration functions at a higher rate than normal due to elevated hormones.
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